Rh-catalyzed highly enantioselective formation of functionalized cyclopentanes and cyclopentanones.

نویسندگان

  • Fei Liu
  • Qiang Liu
  • Minsheng He
  • Xumu Zhang
  • Aiwen Lei
چکیده

A catalyst system, [Rh(COD)Cl](2)-BINAP-AgSbF(6), has been developed as a second-generation catalyst for the cycloisomerization of 1,6-enynes tethered by carbon chains. Cyclopentanes and cyclopentanones, which can contain functional groups, such as the 1,4-dienes, vinyl ether, aldehyde etc., were obtained from readily available starting materials in high yields and selectivities. Both regioselectivities and enantioselectivities are excellent: only 1,4-dienes were observed and in over 99% ee.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 5 21  شماره 

صفحات  -

تاریخ انتشار 2007